Table 3.
Predictors of RSV-Neutralizing Antibody Levels and Transfer in HIV-Infected Mothers and HIV-Exposed, Uninfected Infants
| Characteristic | N | GMT or Antibody Transfer Ratio (95% CI) | P a |
|---|---|---|---|
| Maternal RSV Antibodies | |||
| Maternal CD4+ count (cells/μL) | .09 | ||
| <350 | 36 | 3172 (2637–3925) | |
| ≥350 | 93 | 2915 (2165–3815) | |
| Maternal viral load (copies/mL) | .69 | ||
| <400 | 92 | 3339 (2759–4041) | |
| ≥400 | 12 | 2216 (1406–3492) | |
| RSV antibody transfer | |||
| Infant birth weight (g) | .004 | ||
| <3000 | 72 | 0.94 (0.80–1.07) | |
| ≥3000 | 82 | 1.10 (0.97–1.23) | |
| Maternal CD4+ count (cells/μL) | .30 | ||
| <350 | 36 | 0.95 (0.75–1.16) | |
| ≥350 | 93 | 1.02 (0.90–1.14) | |
| Maternal viral load (copies/mL) | .01 | ||
| <400 | 92 | 1.06 (0.94–1.18) | |
| ≥400 | 12 | 0.55 (0.33–0.77) | |
| Infant RSV antibodies | |||
| Infant birth weight (g) | .10 | ||
| <3000 | 72 | 2487 (1906–3246) | |
| ≥3000 | 82 | 2815 (2282–3474) | |
| Maternal CD4+ count (cells/μL) | .37 | ||
| <350 | 36 | 2205 (1714–2837) | |
| ≥350 | 93 | 2758 (2200–3458) | |
| Maternal viral load (copies/mL) | .02 | ||
| <400 | 92 | 3010 (2411–3759) | |
| ≥400 | 12 | 1046 (645–1695) |
Abbreviations: CI, confidence interval; GMT, geometric mean titer; HIV, human immunodeficiency virus; RSV, respiratory syncytial virus.
a P values were estimated from multivariable linear regression; all models were adjusted for age and enrollment month.