. 2020 Jul 9;12:5597–5605. doi: 10.2147/CMAR.S261585

Table 1.

Definitions of Cancer Cachexia

Study	Criteria
Evans et al⁹	Weight loss of at least 5% in 12 months or less in the presence of underlying illness, plus three of the following criteria: -Decreased muscle strength (lowest tertile) -Fatigue -Anorexia -Low fat-free mass index -Abnormal biochemistry Increased inflammatory markers (CRP>5.0mg/l, IL-6>4.0pg/mL); Anemia (HGB<12g/dl); Low serum albumin (Alb<3.2g/dl)
Fearon et al (EPCRC)¹⁰	-Weight loss>5% over past 6 months (in absence of simple starvation); or -BMI<20 and any degree of weight loss>2%; or -Appendicular skeletal muscle index consistent with sarcopenia (male<7.26kg/m²; female<5.45kg/m²) and any degree of weight loss>2%
SCRINIO²¹	-Weight loss ≥10%; and -Presence of at least 1 symptom of anorexia, fatigue, or early satiation.

Study

Criteria

Evans et al⁹

Weight loss of at least 5% in 12 months or less in the presence of underlying illness, plus three of the following criteria:
-Decreased muscle strength (lowest tertile)
-Fatigue
-Anorexia
-Low fat-free mass index
-Abnormal biochemistry

Increased inflammatory markers (CRP>5.0mg/l, IL-6>4.0pg/mL);

Anemia (HGB<12g/dl);
Low serum albumin (Alb<3.2g/dl)

Fearon et al (EPCRC)¹⁰

-Weight loss>5% over past 6 months (in absence of simple starvation);
or
-BMI<20 and any degree of weight loss>2%;
or
-Appendicular skeletal muscle index consistent with sarcopenia (male<7.26kg/m²; female<5.45kg/m²) and any degree of weight loss>2%

SCRINIO²¹

-Weight loss ≥10%;
and
-Presence of at least 1 symptom of anorexia, fatigue, or early satiation.

Abbreviations: CRP, C-reactive protein; IL-6, interleukin-6; HGB, hemoglobin.