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. 2020 Jul 9;14:2695–2705. doi: 10.2147/DDDT.S255158

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© 2020 Zhang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Let-7 regulated the migration and proliferation of Schwann cells through NGF. (A) Let-7 mimics and pcDNA3.1-NGF were transfected into Schwann cells, and Western blot was used to detect the expression of NGF protein. (B and C) The migration (B) and proliferation (C) of Schwann cells were detected by Transwell assay and EdU assay respectively. (D) Let-7 inhibitors and NGF siRNA were transfected into Schwann cells, and Western blot was used to detect the expression of NGF protein. (E and F) The migration (E) and proliferation (F) of Schwann cells were detected by Transwell assay and EdU assay respectively. **P < 0.01, and ***P < 0.001.

Abbreviation: NGF, nerve growth factor.