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. 2020 Jul 9;15:4877–4898. doi: 10.2147/IJN.S251627

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© 2020 Chen et al.

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Mucus permeation and cytotoxicity studies. (A) Permeantion percentage of insulin NPs in artificial mucus for 2 h. **P < 0.01, N = 3. (B) In vitro cell viability of Caco-2 cells against blank NPs (HA-DCDA-CS-r8 NPs), insulin-loaded NPs (HA-DCDA-CS-r8-INS NPs), and insulin with different concentration by MTT. *P < 0.05 vs the concentration of 0 μg/mL. N = 5.