Table 1. Summary of previously reported metal imaging in toxicological studies.
| Authors | Disease | Pharmaceutical | Target metals | Significance |
|---|---|---|---|---|
| Moreno-Gordaliza et al. | Nephrotoxicity (Rats) | Cisplatin | Pt, Cu, and Zn | Cu and Zn distribution maps revealed significant displacement in cells by Pt |
| Bonta et al. | Pleural mesothelioma (Human) | Cytostatic drugs | Pt | Quantitative Pt imaging coupled with histological images of malignant areas (H&E staining and anti-CD34) |
| Egger et al. | Normal (Mice) | Cisplatin and KP1339 | Pt and Ru | Quantitative ICP-MS imaging validated using conventional ICP-MS methods |
| Van Acker et al. | Nephrotoxicity (Cynomolgus monkeys) | Cisplatin | Pt | Comparison of high-resolution H&E staining results and the Pt distribution |
| Schreiber-Brynzak et al. | Tumor hypoxia model (cancer spheroids and xenografts) | Satraplatin and Pt-containing chemicals | Pt | Comparison and description of differences between hypoxia and non-hypoxic conditions |