Fig 6. Combination of venetoclax and AMG-176 in CLL cells.
CLL lymphocytes from 5 patients were either vehicle (DMSO) treated or treated with 1, 5, 10, or 30 nM venetoclax (white bars), 100 and 300 nM AMG-176 (light grey bars) or combination of both (dark grey bars) for 24 h. (A - E) Samples from patient 133, 291, 963, 897, and 689 were treated and annexin/PI positivity was measured as described in the Methods section. DMSO value was subtracted from % cell death obtained after each treatment. Abbreviations used are A = AMG-176; V = venetoclax.