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. Author manuscript; available in PMC: 2021 Oct 2.
Published in final edited form as: Platelets. 2020 Jan 14;31(7):952–959. doi: 10.1080/09537104.2020.1714573

Figure 3. The platelet transcriptome is altered in patients with heart failure prior to LVAD implantation.

Figure 3.

Platelets were isolated from heart failure patients prior to LVAD implantation (pre-LVAD, n=14) or matched control donors (Control, n=7). The platelet transcriptome was analyzed by next generation RNA-sequencing and compared between heart failure patients and control donors. (A) Heat map, (B) volcano plot, and (C) Venn diagram of significantly (FDR<0.05) differentially expressed transcripts between heart failure patients and control donors. In the heat map, each row represents a differentially expressed gene and each column represents a unique patient or control donor. Red indicates transcripts that were significantly upregulated and blue indicates transcripts that were significantly down-regulated. (D) Gene ontology (GO) pathway analysis for significantly differentially expressed transcripts (n=588, FDR<0.05) in heart failure patients compared to control donors.