Fig. 8.

Model for the role of DISC1 in MTOC translocation. (A) The DISC1 and the dynein complexes become concentrated at a central location at the nascent immunological synapse where they are possibly linked to actin. At this stage, dynein can draw the MTOC linearly towards the synapse. (B) Subsequently, congruous with cell spreading, the DISC1–dynein complex becomes linked to talin and LFA-1 at the pSMAC. (C) In the absence of DISC1, dynein still concentrates at a central region and can draw the MTOC towards the synapse. (D) In the absence of DISC1, cells do not spread and the dynein complex remains concentrated at a central location at the synapse. In this case, compared to WT cells, the MTOC does not come all the way to the synapse.