Figure 1.

Forest plot of the meta-analysis of ACE2 lung gene expression. Data are Hedges’ g effect size (standardized mean difference in log₁₀ scale) and the lines represent the 95% CI. Square sizes are proportional to weight. CHDPAH samples were from GSE113439; CTDPAH samples were from GSE113439 and GSE53408; and IPAH samples were from GSE113439, GSE15197, and GSE53408. The GSE53408 dataset did not identify the PAH subtypes. n indicates patients vs controls. Only samples with PAH (class I pulmonary hypertension) were included. CHDPAH, congenital heart disease–associated pulmonary arterial hypertension; CTDPAH, connective tissue disease–associated pulmonary arterial hypertension; IPAH, idiopathic pulmonary arterial hypertension; PAH, pulmonary arterial hypertension.