Table 1.

Overview on μPET and immunohistochemistry (IHC) results

Mouse strain

Age (months)

PET (n)

TSPO CTX

TSPO HIP

TSPO BRST

TSPO CBL

Age (months)

IHC (n)

IBA1 CTX

IBA1 BRST

CD 68 CTX

CD68 BRST

AT8 CTX

AT8 BRST

P301S

1.9

33

0.64 ± 0.07

0.90 ± 0.06

0.96 ± 0.07

0.86 ± 0.07

2.7

3

0.19 ± 0.04

0.18 ± 0.01

–

–

2.63 ± 0.76

4.12 ± 0.12

3.9

32

0.70 ± 0.07

0.93 ± 0.07***

0.99 ± 0.07**

1.06 ± 0.10

4.8

3

0.25 ± 0.05

0.20 ± 0.04

–

–

3.70 ± 0.89

4.56 ± 0.04

6.4

29

0.85 ± 0.05***

1.05 ± 0.04***

1.28 ± 0.08***

1.31 ± 0.07***

6.6

14

0.49 ± 0.08**

0.38 ± 0.05**

0.31 ± 0.03*

0.36 ± 0.05*

5.57 ± 1.27

5.50 ± 0.95

WT

2.1

18

0.62 ± 0.07

0.88 ± 0.06

0.97 ± 0.07

0.90 ± 0.09

2.7

2

0.19 ± 0.01

0.20 ± 0.02

–

–

–

–

4.1

17

0.67 ± 0.05

0.87 ± 0.04

0.94 ± 0.04

1.03 ± 0.07

4.5

2

0.21 ± 0.01

0.21 ± 3E-4

–

–

–

–

6.5

17

0.76 ± 0.05

0.95 ± 0.03

1.05 ± 0.04

1.11 ± 0.05

6.7

5

0.35 ± 0.04

0.25 ± 0.03

0.28 ± 0.02

0.29 ± 0.03

0

0

P301S

Age (months)

PET (n)

FDG CTX

FDG HIP

FDG BRST

FDG CBL

6.4

24

0.78 ± 0.05

0.90 ± 0.03***

1.17 ± 0.04**

1.03 ± 0.05

WT

6.1

16

0.75 ± 0.05

0.95 ± 0.05

1.22 ± 0.05

1.04 ± 0.05

PET values are reported as SUVRNAC. p values were calculated by two-way t test or Mann Whitney U test of P301S vs age-matched wild-type (WT) mice

FDG¹⁸F-Fluorodesoxyglucose, CTX cortex, HIP hippocampus, BRST brainstem, CBL cerebellum

*p < 0.05, **p < 0.01, ***p < 0.001