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. 2020 Jul 13;21:171. doi: 10.1186/s13059-020-02072-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — a Methylation × number of exons × proportion of splicing genes—promoter. b Methylation × number of exons × proportion of splicing genes—gene body. c Bar plot of the 41 TFs with significant regression coefficients in the logistic regresssion. Positive coefficients predict DAST, and negative coefficients predict DGE. d Multidimensional scaling of TF interaction profiles of DAST (blue) and DGE (green) genes