Table 1.
Genes regulated predominantly by alternative splicing (AS genes) differ from genes regulated predominantly by differential expression (DE genes) with respect to a number of characteristics related to DNA sequence, methylation, and transcription factor binding. Entries shown as percentages indicate the percentage of all genes in the group that display the characteristic. MW Mann-Whitney test, FET Fisher exact test, W Wald test. Additional methylation results are listed in Supplementary Table S9
| Predictor | DAST genes | DGE genes | p value |
|---|---|---|---|
| Promoter methylation age 0 | 34.66 | 25.09 | 1.69×10−23 (MW) |
| ZFX binding | 57.5% | 35.8% | 1.83×10−8 (W) |
| Number of exons | 34 | 21 | 4.22×10−106 (MW) |
| Total gene length | 72,367 bp | 76,408 bp | 5.81×10−6 (MW) |
| Dispersion | 27.32 | 27.92 | 6.62×10−3 (MW) |
| CpG island | 77% | 61.3% | 1.52×10−26 (FET) |
| TATA box | 5.5% | 12.9% | 2.32×10−15 (FET) |
| Number of transcripts | 11.4 | 6.9 | 4.94×10−152 (MW) |
| Exon length | 240 bp | 250 bp | 4.35×10−28 (MW) |