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. 2020 Jul 13;6:7. doi: 10.1186/s40959-020-00064-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — In vivo effects of sorafenib. Panel a: trace recording of blood pressure in anaesthetised rats receiving acute administration of dimethyl sulfoxide (DMSO, 50 μl at 1/1000) or sorafenib. Panel b: Dose-response curve of sorafenib (0.1, 0.3 and 1 mg/kg iv) on mean blood pressure (MBP). Each bar is the mean ± SEM of 6 rats. * P < 0.05; ** P < 0.01 compared to the first dose; †† P < 0.01, ††† P < 0.001 compared to NaCl and DMSO. One factor ANOVA followed by Fisher PLSD. Panel c: protocol for chronic treatments. Panel d: Evolution of systolic blood pressure (SBP) in conscious normotensive rat for 4 weeks treatment with sorafenib. Each point is the mean ± SEM of 4–6 rats. * P < 0.05 compared to Day 0; † P < 0.05 compared to Control