Table 1.

Summarized results of studies which assessed expression of TINCR in cell lines (Δ: knock-down, Human gastric epithelial cell line (GES-1), Human normal esophageal epithelial cell line (HEEC), Human normal oral epithelial keratinocytes (HOK), The human bronchial epithelial cells (HBE), human normal breast epithelial cell line (MCF-10A), Normal human prostate epithelial cell lines (RWPE-1 and P69), SV-40-immortalized human uroepithelial cell line (SV-HUC-1), Human normal liver epithelial cell line (THLE‐2)).

Cancer type	Targets/Regulators and Signaling Pathways	Assessed cell lines	Function	Reference
Gastric cancer	STAU1, KLF2, CDKN2B/P15 and CDKN1A/P21	MGC803, BGC823, MKN45 and SGC7901, and the normal gastric epithelium cell line GES1	Δ TINCR: ↓ cell proliferation, ↓ colony formation, ↓ tumorigenicity, ↑ apoptosis ↑ TINCR: ↑ cell growth, ↑ cell cycle progression	[6]
	E2F1/TINCR/STAU1/CDKN2B signaling axis	MGC803, BGC823, MKN45, AGS, SGC7901 and GES-1	Δ TINCR: ↓ cell proliferation	[11]
	–	HGC27, AGS, SGC-7901, MGC803 and GES-1	An approximately two-fold upregulated expression could be observed in GC cell lines for the lncRNAs TINCR.	[10]
	miR-375/PDK1	KATO III, NCI-N87, HGC-27, and SNU-1	Δ TINCR: ↑ apoptosis, ↓ cell proliferation	[4]
Colorectal cancer	miR‐7‐5p/PI3K/Akt/mTOR signaling pathway	HCT116, HCT8, HT29, SW620 and SW480	↑ TINCR: ↑ proliferation, ↑ migration, ↑ invasion	[12]
	Wnt/β-catenin pathway	LoVo, RKO, SW620, HCT116, SW480 and LS174T	Δ TINCR: ↑ proliferation, ↑ migration, ↑ invasion	[7]
	–	SW620 and HTC116 cells	↑ TINCR: ↓ proliferation, ↓ migration	[13]
Esophageal squamous cell carcinoma (ESCC)	–	TE-13, KYSE-410, ECA-109, TE-1 and HEEC	Δ TINCR: ↓ proliferation, ↓ migration, ↓ invasion, ↓ progression of cell cycle, ↑ apoptosis	[22]
Squamous cell carcinoma (SCC)	ZNF750	93UV147, UMSCC1, CaSki	Δ TINCR: ↑ cell growth, ↑ migration, ↓ activation of differentiation-related gene	[24]
Oral squamous cell carcinoma (OSCC)	Wnt/β-catenin signaling pathway	SCC-9, CAL-27, HOK	Δ TINCR: ↓ proliferation, ↓ migration, ↓ invasion	[23]
Cutaneous squamous cell carcinoma (CSCC)	ERK1/2‐SP3 pathway	A431	Δ TINCR: ↓ apoptosis, ↓ autophagy	[27]
Non-small cell lung cancer (NSCLC)	MAPK signaling pathway	MRC-5, PC9, H1299, H522, A549, 95D, 95C, H2172 and 293T	Δ TINCR: ↓ migration, ↓ viability	[14]
	miR-29b	A549, H1299, H1650 and the human large cell lung cancer cells H460	Δ TINCR: ↓ proliferation	[28]
	miR-21	H650 and H1581	↑ TINCR: ↓ migration, ↓ invasion	[15]
Lung cancer	miR-544a/FBXW7	A549, H322, H460, GLC-82, SPC-A1 and HBE	↑ TINCR: ↓ proliferation, ↓ invasion	[29]
Hepatocellular carcinoma (HCC)	miR-137/miR-133a	HUH7	TINCR expression was suppressed by miR-137/miR-133a and it may play an oncogenic role in HCC differentiation, invasion, and metastasis.	[30]
	p53	SNU-182 and SNU-398	↑ TINCR: ↑ apoptosis	[16]
	miR-214-5p/ROCK1	H1581 and SNU-475	↑ TINCR: ↑ proliferation	[18]
	miR‐218‐5p/DDX5/AKT signaling	PLC/PRF/5, Hep3B, Huh7, HCCLM3 and THLE‐2	Δ TINCR: ↓ proliferation, ↓ invasion, ↑ apoptosis	[18]
Glioma	RPL36/STAT1/CDK2	U87MG and U251	↑ TINCR: ↓ proliferation, ↑ G1/S cell cycle arrest	[25]
Breast cancer	–	MDA-MB-453 and MCF-7	Δ TINCR: ↓ proliferation, ↑ apoptosis, ↓ cell cycle progression	[20]
	miR-7/KLF4	MCF-10A, MDA-MB-231, MDA-MB-435, MDA-MB-453, MDA-MB-468 and MCF-7	Δ TINCR: ↓ migration, ↓ invasion	[19]
	miR-125b, HER-2 and Snail-1	Trastuzumab-resistant SKBR-3-TR and BT474-TR cell lines	Δ TINCR: ↓ Trastuzumab resistance, ↓ epithelial-mesenchymal transition	[21]
Prostate cancer	TRIP13	LNCaP, PC3, DU145, 22Rv1, RWPE-1 and P69	↑ TINCR: ↓ proliferation, ↓ migration, ↓ invasion	[5]
Bladder cancer	–	5637 cells, SW780, SV-HUC-1	Δ TINCR: ↓ cell growth, ↑ apoptosis	[31]
Retinoblastoma	PTEN	Y79 and WERI-Rb-1	↑ TINCR: ↑ apoptosis	[26]