Table 2.

Summary of studies which assessed function of TINCR in animal models (Δ: knock down or deletion).

Cancer type	Animal models	Function and comments	Reference
Gastric cancer	Athymic (nu/nu) mouse models	Δ TINCR: ↓ tumorigenesis of GC cells, ↓ tumor weight and size	[6]
	Nude mice	Δ TINCR: ↓ Tumor growth	[4]
Colorectal cancer	Male BABL/c nude mice	Δ TINCR: ↓ CRC cells growth, ↓ metastasis	[12]
	BALB/c nude mice	Δ TINCR: ↑ Tumor growth, ↑ metastasis	[7]
Oral squamous cell carcinoma (OSCC)	male BALB/c nude mice	↑ TINCR: ↑ Tumor growth, ↑ metastasis	[23]
Non-small cell lung cancer (NSCLC)	Nude mice	Δ TINCR: ↓ Tumor growth, ↓ tumor weight	[14]
	Nude mice	Δ TINCR: ↓ Tumorigenesis	[28]
Hepatocellular carcinoma (HCC)	BALB/c nude mice	Δ TINCR: ↓ Tumor growth, ↓ tumor weight	[18]
Glioma	Female BALB/c nude mice	↑ TINCR: ↓ Tumor growth, ↓ tumor weight	[25]
Breast cancer	Female BALB/c nude mice	Δ TINCR: ↓ Tumor growth	[19]
	Male BALB/c nude mice	Δ TINCR: ↓ Trastuzumab resistance, ↓ metastasis	[21]