Table 3.

Summary of studies reported expression of TINCR in clinical samples (Gastrointestinal stromal tumors (GIST), Head and neck Squamous cell carcinoma (HNSCC), Disease free survival (DFS), overall survival (OS)).

Cancer type	Numbers of clinical samples (tissues, serum, etc.)	Expression (Tumor vs. Normal)	Kaplan-Meier analysis	Univariate cox regression	Multivariate cox regression	Reference
Gastric cancer (GC)	80 primary GC tissue samples and paired adjacent non-tumor tissue samples	Up	The high TINCR patients had higher recurrence rates than the low-TINCR patients.	TINCR expression was a significant prognostic indicator of DFS in patients with GC	TINCR expression was a significant prognostic indicator of DFS in patients with GC	[6]
	Plasma samples from 162 patients with GC, 110 healthy controls, 28 patients with precancerous lesions and 21 with GIST	Up	–	–	–	[10]
	56 primary GC tissue samples and paired adjacent non-tumor tissue samples	Up	–	–	–	[4]
Colorectal cancer	80 pairs of CRC tissues and adjacent non-tumor tissues, 80 CRC plasma and 80 normal control	Up	High expression of TINCR predicted a poor OS (p < 0.001).	High expression of TINCR was predictors for poor OS.	High expression of TINCR was an independent predictor of poor OS.	[12]
	44 CRC tissues and their paired normal colorectal mucosa	Down	–	–	–	[7]
Esophageal squamous cell carcinoma (ESCC)	56 pairs of primary ESCC tissues and adjacent normal tissues	Up	–	–	–	[22]
Squamous cell carcinoma (SCC)	TCGA cohort of HNSCC patients	Down	Low levels of TINCR were significantly correlated with poor outcome of patients with HNSCC.	–	–	[24]
Oral squamous cell carcinoma (OSCC)	48 pairs of primary OSCC tissues and adjacent normal tissues	Up	Patients with high TINCR had reduced OS and progressive-free survival rates, compared with patients with low expression of this lncRNA.	–	–	[23]
Non-small cell lung cancer	98 pairs of NSCLC tissues and normal adjacent tissues	Up	High TINCR expression was correlated with poor survival.	–	–	[14]
	37 pairs of NSCLC tissues and normal adjacent tissues	Up	–	–	–	[28]
	70 pairs of NSCLC tissues and normal adjacent tissues	Down	Patients with low TINCR levels in NSCLC tissues had much worse survival rate.	–	–	[15]
Lung cancer	45 cases of lung cancer tumor tissues and adjacent normal tissues	Down	–	–	–	[29]
Hepatocellular carcinoma (HCC)	248 pairs of HCC tissues and normal adjacent tissues	Up	Patients with high TINCR expression tended to have worse DFS and OS.	–	TINCR was an independent poor prognostic indicator for DFS and OS in HCC.	[30]
	66 pairs of HCC tissues and normal adjacent tissues	Down	Low TINCR levels in HCC tissues were associated with low 5-year OS.	–	–	[16]
	60 pairs of HCC tissues and normal adjacent tissues	Up	–	–	–	[18]
	56 pairs of HCC tumor tissues and adjacent normal liver tissues	Up	High TINCR expression was correlated with worse OS.	–	–	[18]
Glioma	61 pairs of glioma tissues and normal adjacent tissues	Down	–	–	–	[25]
Breast cancer	26 GEO datasets with 4140 breast cancer including patients' long-term follow-up information	Up	High TINCR expression was correlated with worse OS.	–	–	[20]
	24 cases of breast cancer tumor tissues and adjacent normal tissues	Up	High TINCR expression was correlated with worse prognosis.			[19]
	60 patients with HER-2+ breast cancer who underwent surgical resection followed by trastuzumab treatment and primary cancer tissues before performing trastuzumab treatment	Up	High TINCR expression was associated with poor survival in patients receiving trastuzumab therapy.	–	–	[21]
Prostate cancer	52 pairs of normal prostatic tissues and prostate cancer tissues from TCGA database, Fresh 160 prostate cancer tissue specimens and 30 paired normal prostatic tissue specimens from 160 patients	Down	Level of TINCR is positively correlated with the OS of prostate cancer cases.	TINCR low expression was an unfavorable prognostic factor for prostate cancer patients.	–	[5]
Bladder cancer (BCa)	49 paired BCa tissues and corresponding noncancerous tissues	Up	–	–	–	[31]
Retinoblastoma (RB)	60 pairs of RB tissues and normal adjacent tissues	Down	–	–	–	[26]