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. 2020 Jun 25;21:441–451. doi: 10.1016/j.omtn.2020.06.017

Figure 4.

Figure 4

IRAK1 Is a Functional Target of miR-192

(A) The predicted miR-192 seed sequence in the IRAK1 3′ UTR region is shown. (B) Luciferase activity of the reporter plasmid containing WT or Mut IRAK1 3′ UTR cotransfected into human embryonic kidney 293T (HEK293T) cells with miR-192 or control. (C) Luciferase activity of the reporter plasmid containing WT or Mut IRAK1 3′ UTR cotransfected into HEK293T cells with scrambled control or miR-192 inhibitor. (D) Expression of IRAK1 in BMDMs transfected with scrambled control or miR-192 inhibitor. The data are expressed as the mean ± SEM of three independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.