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. 2020 Jul 7;11:1138. doi: 10.3389/fimmu.2020.01138

Figure 9.

Figure 9

Anti-Coprococcus antibody responses in TMEV infection. (A) Using ELISA plates coated with Coprococcus antigen, we titrated serum anti-Coprococcus antibody responses in naive mice (n = 7), chronically TMEV-infected mice (n = 5), and Coprococus-sensitized mice (n = 10). We did not find significantly increased anti-Coprococcus antibody responses in TMEV infection (P = 0.65, ANOVA, compared with naive mice). *P < 0.05, **P < 0.01, ANOVA, compared with Coprococcus-sensitized mice. (B,C) We conducted anti-TMEV IgG1 (B) and IgG2c (C) isotype antibody ELISAs using sera in chronic TMEV infection. We incubated the sera overnight in the absence (None, white bar) or the presence of TMEV antigen (black bar), Coprococcus antigen (gray bar), Helicobacter pylori antigen (hatched bar), or myelin oligodendrocyte glycoprotein (MOG) peptide (cross-hatched bar). Only the adsorption of TMEV antigen decreased anti-TMEV antibody isotype responses. Shown are mean + SE of antibody titers of five sera per group.