Table 3.

Univariate and multivariate analyses: association between patients characteristic and early progression.

	Univariate analysis		Multivariate analysis
	OR (95% CI)	P	OR (95% CI)	P
Age (>65 vs. <65)	3.32 (104–10.58)	0.042*	2.71 (0.74–9.97)	0.132
BMI (overweight vs. other)	1.33 (0.36–4.92)	0.666	–
Sex (female vs. male)	0.85 (0.26–2.74)	0.795	–
Histology (sq vs. non-sq)	0.34 (0.11–1.06)	0.065	–
ECOG (PS 1 vs. PS 0)	7.15 (1.75–29.20)	0.006*	6.80 (1.45–31.74)	0.015*
Brain metastasis (yes vs. no)	1.76 (0.29–10.55)	0.536	–
Lung metastasis (yes vs. no)	0.30 (0.07–1.28)	0.104	–
Pleural effusion (yes vs. no)	0.80 (0.14–4.42)	0.806	–
Liver metastasis (yes vs. no)	3.5 (0.65–18.75)	0.144	–
Kyn/trp median (≤0.06 vs. >0.06)	0.25 (0.07–0.86)	0.028*	0.24 (0.05–1.08)	0.064*

OR, odds ratio; BMI, body mass index; Sq, squamous; ECOG, Eastern Cooperative Oncology Group; PS, performance status;

^*Statistical significance was set at p < 0.05.