Table 1.
The demographics and clinical characteristics of patients with branch atheromatous disease.
| Variables | Unmatched Cohort | Matched Cohort | ||||
|---|---|---|---|---|---|---|
| Alteplase Group (n = 51) | Control Group (n = 84) | P-value | Alteplase Group (n = 42) | Control Group (n = 42) | P-value | |
| Age, mean ± SD, year | 59.1 ± 12.2 | 64.2 ± 12.5 | 0.834 | 59.3 ± 11.9 | 63.7 ± 14.7 | 0.168 |
| Male, n (%) | 32 (62.7) | 60 (71.4) | 0.294 | 25 (59.5) | 32 (76.2) | 0.102 |
| Risk factors | ||||||
| Hypertension, n (%) | 34 (66.7) | 51 (60.7) | 0.487 | 27 (64.3) | 26 (61.9) | 0.821 |
| Hyperlipidemia, n (%) | 25 (49.0) | 36 (42.9) | 0.485 | 22 (52.4) | 17 (40.5) | 0.274 |
| Diabetes, n (%) | 11 (21.6) | 26 (31.0) | 0.236 | 11 (26.2) | 14 (33.3) | 0.474 |
| Smoking, n (%) | 17 (33.3) | 22 (26.2) | 0.375 | 11 (26.2) | 9 (21.4) | 0.606 |
| History of ischemic stroke, n (%) | 3 (5.9) | 15 (17.9) | 0.047 | 3 (7.1) | 5 (11.9) | 0.713 |
| Blood pressure at admission | ||||||
| SBP, mean ± SD, mmHg | 152.2 ± 21.1 | 154.1 ± 23.4 | 0.371 | 150 (138, 166) | 155 (126, 180) | 0.213 |
| DBP, median (IQR), mmHg | 88 (76, 99) | 85 (76, 99) | 0.414 | 89 (76, 95) | 89 (76, 104) | 0.629 |
| Baseline blood glucose, median (IQR), mmol/L | 5.4 (5.0, 6.3) | 5.8 (5.1, 7.0) | 0.370 | 5.4 (5.0, 6.3) | 5.9 (5.3, 7.3) | 0.181 |
| Onset-to-needle time, median (IQR), hours | 3 (3, 4) | 3 (2, 4) | 0.648 | 3 (2, 4) | 3 (2, 4) | 0.790 |
| Baseline NIHSS score, median (IQR) | 7 (4, 9) | 4 (3, 6) | <0.001 | 5 (4, 8) | 5 (4, 7) | 0.664 |
| NIHSS score at discharge, median (IQR) | 2 (0, 5) | 4 (2, 6) | 0.009 | 2 (0, 4) | 4 (3, 8) | <0.001 |
| Hospital stay, median (IQR), days | 9 (6, 12) | 11 (9, 14) | 0.005 | 9 (6, 11) | 12 (9, 15) | 0.001 |
| Infarct site | ||||||
| The lenticulostriate artery, n (%) | 37 (72.5) | 59 (70.2) | 0.774 | 30 (71.4) | 30 (71.4) | 1.000 |
| The paramedian pontine artery, n (%) | 14 (27.5) | 25 (29.8) | 0.774 | 12 (28.6) | 12 (28.6) | 1.000 |
| Dual antiplatelet treatment, n (%) | 48 (94.1) | 79 (94.0) | 0.987 | 39 (92.9) | 41 (97.6) | 0.616 |
SD, standard deviation; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure; DBP, diastolic blood pressure.