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. 2020 Jul 7;11:1465. doi: 10.3389/fimmu.2020.01465

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Copyright © 2020 Dutta and Schneider.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental sketch for preclinical examination of sex-differences in responsiveness to HDTs. The experimental strategy would help to determine sex-based differences in clinical, microbiological, immunological and histopathological outcomes in M. tuberculosis infected (i) C3HeB/FeJ male and female mice and (ii) human monocyte-derived macrophages from healthy male and female donors before and after treatment with HDTs. Several untargeted and targeted approaches can be used to investigate the molecular mechanisms associated with the sex-specific anti-TB activity of HDTs. MDMs, monocyte-derived macrophages; shRNA, Small hairpin RNA.