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. 2020 Jul 7;10:1094. doi: 10.3389/fonc.2020.01094

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Copyright © 2020 Li, Zhang, Zhang, Yao, Yang, Fan and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo effects of AMPK activator/AMPK antibody/Angustoline on KYSE450 tumor-bearing nude mice. (A) Treatment of AMPK antibody/AMPK activator/Angustoline/(AMPK antibody + Angustoline)/(AMPK activator + Angustoline) on the size of KYSE450 tumors. (B) Relative tumor volume, which was calculated by each tumor volume. *p < 0.05, comparing with the control, n = 5. (C) Tumor suppression rate, which was calculated by each tumor weight. *p < 0.05, comparing with the control, n = 5. (D) Relative tumor proliferation rate, which was calculated by relative tumor volumes of different groups. *p < 0.05, comparing with the control, n = 5.