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. 2020 Jul 7;11:797. doi: 10.3389/fphys.2020.00797

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Copyright © 2020 Poteres, Hubert, Poludasu, Brigando, Moore, Keeler, Isabelli, Ibay, Alt, Pytynia, Ciancio and Martinez-Guryn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antibiotic-treated mice display reduced body fat and plasma lipid levels. C57Bl6 mice were fed a low (LF) or high fat (HF) diet and treated with vehicle control, rifaximin or an antibiotic (Abx) cocktail for 4 weeks. (A) Body weight was measured and expressed as percentage from baseline. (B) Body fat mass was estimated based on the summation of fat pad weights expressed as a percentage of body weight. Liver weight was measured in grams and then expressed as a percentage of total body weight (C). Plasma triglyceride (D) and low density lipoprotein were measured (E). Data are shown as means ± SEM; n = 5 per group; *p < 0.05, **p < 0.01.