Table 3. Summary of the cross-sectional age-corrected QSM observations between control subjects and lumbar and cervical onset ALS respectively at baseline. Statistical significance measured with Wilcoxon rank sum test (one-tailed).
| ROI | QSM (ppb) | Lumbar onset ALS vs. control subjects | Cervical onset ALS vs. control subjects | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Control subjects, mean ± SEM | Lumbar onset ALS, mean ± SEM | Cervical onset ALS, mean ± SEM | P value adjusted | Cohen’s d | P value adjusted | Cohen’s d | |||
| Left primary motor area (anterior) | 27.8±0.9 | 30.8±1.1 | 29.2±1.8 | 0.07 | 1.09 | 0.40 | 0.40 | ||
| Right primary motor area (anterior) | 29.7±1.1 | 34.4±1.9 | 32.5±1.2 | 0.07 | 1.21 | 0.36 | 0.81 | ||
| Left primary motor area (posterior) | 27.0±0.8 | 30.5±1.32 | 29.8±2.5 | 0.07 | 1.34 | 0.40 | 0.70 | ||
| Right primary motor area (posterior) | 28.3±0.8 | 31.2±1.5 | 30.2±2.0 | 0.07 | 1.01 | 0.40 | 0.52 | ||
| Left pre-motor area | 23.1±0.6 | 25.9±2.0 | 23.5±0.6 | 0.13 | 0.94 | 0.40 | 0.22 | ||
| Right pre-motor area | 23.2±0.53 | 26.6±2.2 | 23.1±0.6 | 0.07 | 1.12 | 0.40 | −0.08 | ||
QSM, quantitative susceptibility mapping; ALS, amyotrophic lateral sclerosis; SEM, standard error of the mean; ROI, region of interest.