Table 2.
Summary table of autophagy in lymphocytes.
| Autophagy-related gene | Cell type | Function of autophagy | References |
|---|---|---|---|
| Atg3 | CD8+ T cells | Survival and mitochondrial maintenance | (104, 105) |
| iNKT | Memory formation and mitochondrial maintenance | (106) | |
| Atg5 | CD8+T cells | Homeostasis and survival | (107, 108) |
| Activation and proliferation | (107) | ||
| Memory maintenance | (109, 110) | ||
| CD4+ T cell | Homeostasis and survival | (107) | |
| Activation and proliferation | (107, 111) | ||
| Memory maintenance | (112) | ||
| FoxP3 expression | (113) | ||
| B cells | Plasma cell survival and Ig production | (114, 115) | |
| Mature B cell homeostasis and survival | (116) | ||
| Peripheral B cell homeostasis and survival | (117) | ||
| Internalization of BCR to MHC-II vesicles | (118) | ||
| ILC2 | Homeostasis and survival | (27, 119) | |
| Effector function | (27) | ||
| Metabolic homeostasis | (27) | ||
| iNKT | Homeostasis and survival | (120) | |
| Effector function | (121) | ||
| Atg7 | CD8+T cells | Homeostasis and survival | (105, 107) |
| Memory maintenance | (109, 110) | ||
| CD4+ T cell | Activation and proliferation | (122) | |
| Effector function | (122) | ||
| FoxP3 expression | (113) | ||
| B cells | Memory maintenance | (123, 124) | |
| B1a B cell homeostasis and survival | (125) | ||
| Plasmablast differentiation | (126) | ||
| iNKT | Homeostasis and survival | (120) |