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. 2020 Jul 7;11:1406. doi: 10.3389/fimmu.2020.01406

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Copyright © 2020 Marzaioli, Canavan, Floudas, Wade, Low, Veale and Fearon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mo-DC from RA exhibit an impaired endocytosis. Monocytes from HC, PsA, or RA patients were differentiated for 7 days with GM-CSF/IL-4. Endocytosis was evaluated in parallel at 4 and 37°C following antigen incubation. (A) Top: Representative plot of Receptor-dependent endocytosis (with OVA-DQ) of cells incubated at 37°C, where the positive population (active endocytosis) can be observed. Bottom: Representative histograms of cells incubated at 4 (white) and 37°C (gray). A clear shift can be observed in immature Mo-DC. Average of at least 3 separate experiments for (B) Receptor-depend endocytosis (with OVA-DQ) and (C) Non-specific macropinocytosis (Lucifer Yellow) HC (n = 4), PsA (n = 4), RA (n = 6). Data are represented as mean ±SEM and differences were evaluated with two-way ANOVA with Tukey post-test. *p < 0.05.