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. 2020 Jul 7;14:685. doi: 10.3389/fnins.2020.00685

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Copyright © 2020 Pan, Xu, Zhang, Liu, Lu, Chen, Tang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rupture of intracranial blood vessels causes blood flow into the subarachnoid space to form subarachnoid hemorrhage (SAH). Then hematomas are formed after SAH. Hematoma components include intact red blood cells (RBCs), free hemoglobin (Hb), oxygenated Hb, free heme, and etc. RBC lysis produces free Hb. On the one hand, Hb can bind with oxygen molecules (up to four oxygen molecules) to form oxyhemoglobin; on the other hand, it could be lysed to produce free hemes.