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. 2020 Jul 7;11:432. doi: 10.3389/fendo.2020.00432

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Copyright © 2020 Campi, Covelli, Moran, Fugazzola, Cacciatore, Orlandi, Gallone, Chatterjee, Beck-Peccoz and Persani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flowchart for more effective differential diagnosis of inappropriate TSH secretion. This flow-chart represents our proposed cost-effective work up for the differential diagnosis of inappropriate TSH secretion. Final diagnoses are indicated in bold; optional tests are indicated in parentheses. AD, autosomal dominant; ALB, albumin gene; FDH, Familial dysalbuminemic hyperthyroxinemia (FDH); HAMA, Human anti-mouse antibodies; MEN1, Multiple Endocrine Neoplasia type 1; MLPA, Multiplex Ligation Probe Amplification; MMI, methimazole; NGS, next generation sequence; PEG, polyethylene glycol; SMS-LAR, long-acting-release somatostatin analog; TFTs, thyroid function tests; TH, thyroid hormones; TT4, total T4; TT3, total T3.