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. 2020 Jul 7;11:1412. doi: 10.3389/fimmu.2020.01412

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Copyright © 2020 Dacoba, Anfray, Mainini, Allavena, Alonso, Torres Andón and Crecente-Campo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mRNA production of different M1/M2 associated factors. Fold change in the mRNA levels of IRF7 in (A) prototypic M1/M2 macrophages and in (B) M0 macrophages treated with the different nanocomplexes after 8 h of incubation. The dose of poly(I:C) was 5 μg/mL. Values represent mean ± SD (N = 4). Statistical comparison was done using an ordinary one-way ANOVA followed by a Tukey's comparison test between groups. Statistically significant differences are represented as ***p < 0.005. C12r8, laurate-octaarginine; HA, hyaluronic acid; pArg, poly-arginine; PEG–PGA, pegylated polyglutamic acid; pIC, poly(I:C).