Table 1.
Summary of the main physicochemical properties of the four enveloped nanocomplexes used in the in vitro experiments.
| Formulation | Ratio (w/w) | Particle size (nm) | PDI | ζ-Potential (mV) | Poly(I:C) loading (%) |
|---|---|---|---|---|---|
| pArg:pIC | 1:1 | 163 ± 14 | 0.20 | +44 ± 3 | 50 |
| pArg:pIC /PEG–PGA | 1:1 :3 | 190 ± 14 | 0.18 | +26 ± 8 | 20 |
| pArg:pIC /HA | 1:1 :1.5 | 157 ± 10 | 0.16 | −15 ± 7 | 29 |
| C12r8:pIC /PEG–PGA | 4:1 :3 | 165 ± 14 | 0.07 | +5 ± 1 | 12.5 |
Mean ± SD, n ≥ 12. C12r8, laurate octa-arginine; HA, hyaluronic acid; pArg, polyarginine; PDI, polydispersity index; PEG–PGA, pegylated polyglutamic acid; pIC, poly(I:C); w/w: weight/weight.