Table 4.

Clinically approved peptide antimicrobials.

Antimicrobial	Drug name	Company	Class	Source	Mol Wt	Application	MOA	Dosing	References
Colistin (Polymyxin E)	Coly-Mycin	Generic	Lipopeptide	Bacillus colistinus	1155.4	Antibacterial; Gram -	Membrane disruption	IV, IM and Inhalation	Karaiskos et al., 2017
Dalbavancina	Dalvance	Durata Therapeutics	Lipoglycopeptide	Semi-synthetic	1816.7	Antibacterial; Gram +	Cell wall biosynthesis	IV	Bassetti et al., 2018
Daptomycin	Cubicin	Merck (Cubist)	Lipopeptide	Streptomyces roseosporus	1620.6	Antibacterial; Gram +	Membrane disruption	IV	Gonzalez-Ruiz et al., 2016
Gramicidin D	NA	Generic	Linear peptides	Bacillus brevis	1882.2	Antibacterial; Gram +	Membrane disruption	Topical	Burkhart et al., 1999
Gramicidin S	NA	Generic	Cyclic peptide	Bacillus brevis	1141.4	Antibacterial; Gram + and -	Membrane disruption	Topical	Mogi and Kita, 2009
Oritavancinb	Orbactiv	Melinta Therapeutics	Lipoglycopeptide	Semi-synthetic	1793.1	Antibacterial; Gram +	Cell wall biosynthesis	IV	Saravolatz and Stein, 2015
Polymyxin B	NA	Generic	Lipopeptide	Bacillus polymyxa	1203.5	Antibacterial; Gram -	Membrane disruption	IV and IM	Rigatto et al., 2019
Teicoplanin	Targocid	NPS Pharma	Glycopeptide	Actinoplanes teichomyceticus	1879.6	Antibacterial; Gram +	Cell wall biosynthesis	IV and IM	Campoli-Richards et al., 1990
Telavancinb	Vibativ	Theravance	Lipoglycopeptide	Semi-synthetic	1755.7	Antibacterial; Gram +	Cell wall biosynthesis	IV	Higgins et al., 2005
Vancomycin	NA	Generic	Glycopeptide	Streptomyces orientalis	1449.3	Antibacterial; Gram +	Cell wall biosynthesis	Oral and IV	Alvarez et al., 2016
Anidulafungin	Eraxis	Pfizer	Echinocandin (lipopeptide)	Semi-synthetic	1140.2	Antifungal	Cell wall biosynthesis	IV	Mayr et al., 2011
Caspofungin	Cancidas	Merck	Echinocandin (lipopeptide)	Semi-synthetic	1093.3	Antifungal	Cell wall biosynthesis	IV	Song and Stevens, 2016
Micafungin	Mycamine	Astellas	Echinocandin (lipopeptide)	Semi-synthetic	1270.3	Antifungal	Cell wall biosynthesis	IV	Scott, 2012

IV, Intravenous; IM, Intramuscular; NA, Not applicable;

^aDalbavancin is a semi-synthetic derivative of Teicoplanin;

^bOritavancin and Telavancin are semi-synthetic derivatives of Vancomycin.