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. 2020 Jul 7;11:1005. doi: 10.3389/fphar.2020.01005

Figure 4.

Figure 4

PF-6142 Does not alter the antipsychotic-like activity of risperidone in rodents. (A) As expected, risperidone produced increases % PPI in adult male C57BL/6J mice consistent with an antipsychotic-like profile in this assay. Administration of PF-6142 alone or in combination with risperidone does not alter PPI responses (n=8 per treatment group). (B) Statistically significant reductions in startle responses were observed with the highest dose of risperidone (0.56 mg/kg) which was not altered in the presence of PF-6142. (C) PF-6142 alone produced modest non-significant reductions in % PPI in adult C57BL/6J mice. (D) Risperidone produces significant reductions in avoidance responding consistent with antipsychotic-like activity in adult male rats (n=8–9 per treatment) in the conditioned avoidance responding assay. There is no effect of PF-6142 alone or in combination with risperidone in avoidance responding. One-way ANOVA with Tukey’s post-test adjusted *p < 0.05, **p < 0.01 vs. vehicle + Risperidone (0.56 mg/kg) ***p < 0.001 vs. vehicle + vehicle. Note:2-way RM ANOVA (A). One-way ANOVA with Dunnett’s post-hoc test ****p < 0.0001 vs. vehicle + vehicle (D).