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. 2020 Jul 7;11:1005. doi: 10.3389/fphar.2020.01005

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Copyright © 2020 Kozak, Kiss, Dlugolenski, Johnson, Gorczyca, Kuszpit, Harvey, Stolyar, Sukoff Rizzo, Hoffmann, Volfson, Hajós, Davoren, Abbott, Williams, Castner and Gray

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PF-6142 effects on ketamine-induced working memory deficits. (A) Pre-treatment with PF-6142 dose-dependently prevents ketamine-induced deficits in the rat radial arm maze assay. Data are presented as mean errors + SEM. Kruskal-Wallis test with Dunn’s multiple comparison post-test *p < 0.05, **p < 0.01 vs. vehicle + ketamine. N=10–21. (B) Treatment with PF-6142 prevents ketamine-induced deficits in the non-human primate spatial delayed response task. One-way ANOVA with Dunnett’s post-test adjusted *p < 0.05 vs. vehicle + Ketamine and N = 8 NHP.