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. 2020 Jul 7;11:1005. doi: 10.3389/fphar.2020.01005

Figure 6.

Figure 6

Effects of PF-6142 on NMDA antagonist disrupted paired-pulse facilitation (PPF) and delta oscillations. (A) PF-6142 significantly reverses NMDA blockade-induced changes in PPF. PPF (calculated as P2/P1) values as a function of drug treatment. Note that PF-6142 reverses MK-801-evoked decrease of PPF with an ED50 of 0.35 mg/kg (*: p<0.05 vs. Control, #: p<0.001 vs. MK-801; n=5). The upper and lower hinges on the boxplots show the 25th and the 75th percentiles, respectively, horizontal bar in the boxplot shows median value, whiskers extend to the minimum and the maximum values, “o” indicates data points outside of the 1.5*inter-quartile range of the hinges. (B) PF-6142 significantly reverses NMDA blockade-induced mPFC low frequency delta activity increase. Power contained in the low frequency delta (0–1.8 Hz) band expressed as a percentage of the total delta (0–4 Hz) power. Note that PF-6142 completely reverses MK-801 induced increase of low frequency delta oscillation (*: p<0.02 vs. Control; #: p<0.02 vs. MK-801; n=5). (C) Antagonism of D1Rs blocks effects of PF-6142 on PPF. Figure shows PPF values as a function of drug treatment. Note that administration of SCH-23390 alone had no effect on either the P1 or P2 components or PPF, while this pretreatment completely blocked PF-6142 effects even at high doses. (D) Antagonism of D1Rs blocks effects of PF-6142 on mPFC low frequency delta activity. Power contained in the low frequency delta (0–1.8 Hz) band expressed as a percentage of the total delta (0–4 Hz) power. Note that as with PPF SCH-23390 completely blocks effects of PF-6142 on reversing MK-801-induced changes (*p<0.05 vs. Control, #p<0.03 vs. SCH-23390; n=5).