Table 2.
Representative Exposure Data.
| Species | Dose (mg/kg) | Time (h) | PF-6142 plasma concentration (ng/ml) | Calculated brain D1R occupancy estimate (%) |
|---|---|---|---|---|
| mouse | 5.6 (SC) | 1 | 332 | ~25 |
| rat | 10 (SC) | 1.5 | 1260 | ~55 |
| NHP | 0.1 (SC) | 0.5 | 31 | ~20 |
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