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. 2020 Jul 7;11:1010. doi: 10.3389/fphar.2020.01010

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Copyright © 2020 Gigolaev, Kuzmenkov, Peigneur, Tabakmakher, Pinheiro-Junior, Chugunov, Efremov, Tytgat and Vassilevski

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electrophysiological profiling of MeKTx13-3 and MeKTx13-3_AAAR activities. (A) Representative traces of currents through KV1.1–1.6 in control (black) and after application of 10 nM toxin (blue). (B) Concentration–response curves of MeKTx13-3 (left) and MeKTx13-3_AAAR (right) on KV1.1–1.3 and 1.6 obtained by electrophysiological measurements. IC50 values are listed in Table 1.