Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
IC50 Values (in nM) Calculated for MeKTx13-3 and Its Derivative against KV1.1–1.6.
| Toxin | KV1.1 | KV1.2 | KV1.3 | KV1.4 | KV1.5 | KV1.6 |
|---|---|---|---|---|---|---|
| MeKTx13-3 | 1.9 ± 0.2 (0.9 ± 0.1) | 105.9 ± 14.6 (1.3 ± 0.3) | 8.9 ± 0.9 (0.8 ± 0.2) | N/A | N/A | 63.4 ± 4.5 (1.0 ± 0.1) |
| MeKTx13-3_AAAR | 541.5 ± 48.6 (0.7 ± 0.1) | 208.2 ± 15.2 (1.2 ± 0.1) | 9.1 ± 0.4 (0.7 ± 0.2) | N/A | N/A | 1522.3 ± 183.4 (1.4 ± 0.3) |
N/A means toxin was not active up to 1 µM concentration. Hill coefficient values are given in parenthesis.
