FIGURE 4.

MicroRNAs in cardiac remodeling. The miRNAs involved in the pathogenesis of cardiac fibrosis and hypertrophy are visualized in the inner green and yellow circles, respectively. The miRNAs which have been studied as biomarker are listed in the outer circles. Additionally, the miRNAs studied as therapeutic are shown in blue circles and their initial effect on the pathologies is visualized as a black, stimulatory or inhibitory arrow. The method of intervention is depicted in the green circles and their effect on the miRNA target is shown as a red, stimulatory or inhibitory arrow.