Table 1.
Association studies between CCC and ASY including as covariates the gender and the polymorphisms (genotype associations and allelic tests).
| GENE | Tag SNP | Genotype groups | Association test |
|---|---|---|---|
| IL12B | rs2546890 | GG vs. GA + AA | p = 0.103; OR = 1.231; 95%CI: 0.959–1.579 |
| MAF | ASY MAF(A) = 46.6%; CCC MAF(A) = 40.9% | ||
| Allelic test | Chi-square = 2.11 and p = 0.15 | ||
| rs730691 | GG vs. GA | p = 0.441; OR = 1.274; 95%CI: 0.688–2.358 | |
| MAF | ASY MAF(A) = 9.1%; CCC MAF(A) = 11.1% | ||
| Allelic test | Chi-square = 0.56 and p = 0.46 | ||
| rs2546893 | GG + GA vs. AA | p = 0.002; OR = 1.548; 95%CI: 1.176–2.037 | |
| MAF | ASY MAF(A) = 45.8%; CCC MAF(A) = 35.0% | ||
| Allelic test | Chi-square = 7.89 and p = 0.005 | ||
| rs1003199 | CC + CT vs. TT | p = 0.005; OR = 1.522; 95%CI: 1.134–2.045 | |
| MAF | ASY MAF(T) = 43.1%; CCC MAF(T) = 35.9% | ||
| Allelic test | Chi-square = 3.54 and p = 0.06 | ||
| rs3181216 | TT vs. TA + AA | p = 0.702; OR = 1.047; 95%CI: 0.829–1.321 | |
| MAF | ASY MAF(A) = 21.6%; CCC MAF(A) = 21.8% | ||
| Allelic test | Chi-square = 0.001 and p = 0.97 | ||
| rs2569253 | TT + TC vs. CC | p = 0.039; OR = 1.371; 95%CI: 1.015–1.852 | |
| MAF | ASY MAF(C) = 40.7%; CCC MAF(C) = 35.3% | ||
| Allelic test | Chi-square = 1.87 and p = 0.17 | ||
| rs2853694 | AA vs. AC + CC | p = 0.382; OR = 1.105; 95%CI: 0.884–1.381 | |
| MAF | ASY MAF(C) = 34.7%; CCC MAF(C) = 32.7% | ||
| Allelic test | Chi-square = 0.28 and p = 0.60 | ||
| rs919766 | AA vs. AC + CC | p = 0.001; OR = 1.653; 95%CI: 1.241–2.198 | |
| MAF | ASY MAF(C) = 8.9%; CCC MAF(C) = 19.3% | ||
| Allelic test | Chi-square = 36.67 and p < 0.00001 | ||
| rs2853696 | GG vs. GA + AA | p = 0.981; OR = 1.003; 95%CI: 0.759–1.328 | |
| MAF | ASY MAF(A) = 10.6%; CCC MAF(A) = 10.6% | ||
| Allelic test | Chi-square = 0.002 and p = 0.097 | ||
| rs11574790 | CC vs. CT + TT | p = 0.006; OR = 1.497; 95%CI: 1.124–1.996 | |
| MAF | ASY MAF(T) = 8.3%; CCC MAF(T) = 16.6% | ||
| Allelic test | Chi-square = 8.78 and p = 0.03 | ||
| rs3212227 | AA vs. AC + CC | p = 0.973; OR = 1.004; 95%CI: 0.803–1.254 | |
| MAF | ASY MAF(C) = 31.1%; CCC MAF(C) = 31.0% | ||
| Allelic test | Chi-square = 0.001 and p = 0.97 | ||
| rs1368439 | TT vs. TG + GG | p = 0.735; OR = 1.048; 95%CI: 0.800–1.373 | |
| MAF | ASY MAF(G) = 11.2%; CCC MAF(G) = 10.5% | ||
| Allelic test | Chi-square = 0.073 and p = 0.79 | ||
| rs6870828 | AA vs. AG + GG | p = 0.754; OR = 1.040; 95%CI: 0.814–1.328 | |
| MAF | ASY MAF(G) = 39.4%; CCC MAF(G) = 40.6% | ||
| Allelic test | Chi-square = 0.086 and p = 0.77 | ||
| rs6859018 | CC vs. CT + TT | p = 0.603; OR = 1.093; 95%CI: 0.782–1.527 | |
| MAF | ASY MAF(T) = 33.0%; CCC MAF(T) = 32.5% | ||
| Allelic test | Chi-square = 0.018 and p = 0.89 | ||
| IL10 | rs1800890 | TT vs. TA + AA | p = 0.636; OR = 1.055; 95%CI: 0.845–1.318 |
| MAF | ASY MAF(A) = 26.4%; CCC MAF(A) = 24.7% | ||
| Allelic test | Chi-square = 0.25 and p = 0.62 | ||
| rs1800896 | AA + AG vs. GG | p = 0.013; OR = 1.527; 95%CI: 1.092–2.137 | |
| MAF | ASY MAF(G) = 36.9%; CCC MAF(G) = 32.7% | ||
| Allelic test | Chi-square = 1.24 and p = 0.27 | ||
| rs1800871 | CC + TT vs. CT | p = 0.059; OR = 1.246; 95%CI: 0.992–1.566 | |
| MAF | ASY MAF(T) = 35.3%; CCC MAF(T) = 35.3% | ||
| Allelic test | Chi-square = 0.0001 and p = 0.99 | ||
| rs1518111 | GG + AA vs. GA | p = 0.104; OR = 1.208; 95%CI: 0.962–1.516 | |
| MAF | ASY MAF(A) = 32.4%; CCC MAF(A) = 34.2% | ||
| Allelic test | Chi-square = 0.24 and p = 0.62 | ||
| rs3024496 | TT + TC vs. CC | p = 0.031; OR = 1.437; 95%CI: 1.033–2.000 | |
| MAF | ASY MAF(C) = 40.3%; CCC MAF(C) = 35.0% | ||
| Allelic test | Chi-square = 1.89 and p = 0.17 | ||
| rs6673928 | CC vs. CA | p = 0.329; OR = 2.141; 95%CI: 0.464–9.885 | |
| MAF | ASY MAF(A) = 1.3%; CCC MAF(A) = 0.6% | ||
| Allelic test | Chi-square = 0.95 and p = 0.33 | ||
| IFNG | rs2069705 | TT vs. TC + CC | p = 0.337; OR = 1.12; 95%CI: 0.89–1.41 |
| MAF | ASY MAF(C) = 39.6%; CCC MAF(C) = 37.9% | ||
| Allelic test | Chi-square = 0.20 and p = 0.66 | ||
| rs1861494 | AA vs. AG + GG | p = 0.057; OR = 1.24; 95%CI: 0.99–1.55 | |
| MAF | ASY MAF(G) = 24.3%; CCC MAF(G) = 18.8% | ||
| Allelic test | Chi-square = 3.21 and p = 0.07 | ||
| rs2069718 | CC + CT vs. TT | p = 0.183; OR = 1.18; 95%CI: 0.92–1.52 | |
| MAF | ASY MAF(C) = 48.2%; CCC MAF(C) = 52.4% | ||
| Allelic test | Chi-square = 1.16 and p = 0.28 | ||
| rs2069727 | AA + AG vs. GG | p = 0.232; OR = 1.22; 95%CI: 0.88–1.70 | |
| MAF | ASY MAF(G) = 36.4%; CCC MAF(G) = 38.9% | ||
| Allelic test | Chi-square = 0.45 and p = 0.50 | ||
| rs3181035 | GG vs. GA + AA | p = 0.371; OR = 1.12; 95%CI: 0.88–1.42 | |
| MAF | ASY MAF(A) = 17.0%; CCC MAF(A) = 13.7% | ||
| Allelic test | Chi-square = 1.38 and p = 0.24 | ||
| IL4 | rs2070874 | CC vs. CT + TT | p = 0.481; OR = 1.08; 95%CI: 0.87–1.34 |
| MAF | ASY MAF(T) = 27.0%; CCC MAF(T) = 27.9% | ||
| Allelic test | Chi-square = 0.07 and p = 0.79 | ||
| rs2227284 | AA + AC vs. CC | p = 0.268; OR = 1.15; 95%CI: 0.90–1.46 | |
| MAF | ASY MAF(C) = 53.2%; CCC MAF(C) = 48.2% | ||
| Allelic test | Chi-square = 1.62 and p = 0.20 | ||
| rs2243261 | GG vs. GT + TT | p = 0.651; OR = 1.10; 95%CI: 0.74–1.63 | |
| MAF | ASY MAF(T) = 3.8%; CCC MAF(T) = 4.6% | ||
| Allelic test | Chi-square = 0.26 and p = 0.61 | ||
| rs2243268 | AA vs. AC + CC | p = 0.467; OR = 1.08; 95%CI: 0.86–1.38 | |
| MAF | ASY MAF(C) = 20.0%; CCC MAF(C) = 21.2% | ||
| Allelic test | Chi-square = 0.15 and p = 0.70 | ||
| rs2243274 | GG + GA vs. AA | p = 0.423; OR = 1.15; 95%CI: 0.82–1.60 | |
| MAF | ASY MAF(A) = 31.2%; CCC MAF(A) = 35.8% | ||
| Allelic test | Chi-square = 1.53 and p = 0.22 | ||
| rs2243290 | CC + CA vs. AA | p = 0.352; OR = 1.21; 95%CI: 0.81–1.82 | |
| MAF | ASY MAF(A) = 23.7%; CCC MAF(A) = 24.8% | ||
| Allelic test | Chi-square = 0.12 and p = 0.73 | ||
| rs2406539 | AA vs. AT + TT | p = 0.570; OR = 1.19; 95%CI: 0.65–2.17 | |
| MAF | ASY MAF(T) = 7.5%; CCC MAF(T) = 9.2% | ||
| Allelic test | Chi-square = 0.60 and p = 0.44 |
MAF, Minor Allelic frequency.