Table 3.
Top 20 genomic variants associated with the occurrence of levodopa-induced dyskinesia, in decreasing order of statistical significance.
| Gene | SNP | Chr | Position | Region relative to gene | Allele (minor/major) | Minor allele frequency (case/control) | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|
| GALNT14 | rs144125291 | 2 | 31106055 | Downstream, upstream | T/C | 0.07/0.01 | 5.45 (2.87, 10.33) | 7.88E−09 |
| C17orf51 | rs139221627 | 17 | 21715699 | Upstream | T/C | 0.07/0.02 | 4.68 (2.51, 8.73) | 1.20E−07 |
| C21orf37 | rs208892 | 21 | 18813490 | Intron | A/G | 0.40/0.26 | 1.90 (1.47, 2.45) | 5.74E−07 |
| LRPPRC | rs10495912 | 2 | 44305461 | Upstream, downstream | A/G | 0.07/0.02 | 4.03 (2.24, 7.24) | 5.81E−07 |
| CBFA2T3 | rs150854091 | 16 | 89028784 | Intron | A/G | 0.08/0.02 | 3.64 (2.10, 6.33) | 1.12E−06 |
| TMEM132C | rs1531246 | 12 | 128999121 | Intron | G/C | 0.18/0.09 | 2.28 (1.62, 3.21) | 1.60E−06 |
| SCGB1D4 | rs953169 | 11 | 62083542 | Upstream | G/A | 0.45/0.31 | 1.80 (1.41, 2.31) | 2.57E−06 |
| TMEM158 | rs118109628 | 3 | 45279523 | Downstream, upstream | A/G | 0.03/0.003 | 9.35 (2.96, 29.55) | 3.91E−06 |
| LRPPRC | rs12185607 | 2 | 44296280 | Upstream, downstream | T/G | 0.10/0.04 | 2.86 (1.79, 4.57) | 5.25E−06 |
| ADAM10 | rs118049686 | 15 | 58895720 | Intron | A/G | 0.06/0.02 | 4.07 (2.11, 7.86) | 6.93E−06 |
| LRPPRC | rs17031893 | 2 | 44283172 | Upstream, downstream | G/A | 0.08/0.03 | 3.24 (1.89, 5.55) | 6.96E−06 |
| EXTL3 | rs73564758 | 8 | 28521861 | Intron, downstream | G/A | 0.05/0.01 | 4.58 (2.20, 9.52) | 8.96E−06 |
| ZNF138 | rs117999072 | 7 | 64228326 | Upstream, downstream | A/G | 0.08/0.03 | 3.15 (1.84, 5.37) | 1.06E−05 |
| TTC30B | rs6737342 | 2 | 178419117 | Upstream, downstream | G/A | 0.07/0.02 | 3.37 (1.90, 5.98) | 1.19E−05 |
| HSPH1 | rs143639498 | 13 | 31696395 | Downstream | C/T | 0.05/0.01 | 4.48 (2.15, 9.32) | 1.25E−05 |
| LOC389602 | rs10281583 | 7 | 155811374 | Downstream | A/G | 0.18/0.09 | 2.11 (1.50, 2.97) | 1.30E−05 |
| DUSP26 | rs147270897 | 8 | 34132814 | Intron, upstream | C/T | 0.04/0.01 | 5.39 (2.31, 12.57) | 1.36E−05 |
| SOX17 | rs183607239 | 8 | 55390249 | Downstream, upstream | G/A | 0.03/0.004 | 7.50 (2.59, 21.75) | 1.40E−05 |
| RPL32P3 | rs6795866 | 3 | 129064722 | Exon, downstream | G/A | 0.05/0.01 | 4.59 (2.15, 9.80) | 1.70E−05 |
| TMX1 | rs10129471 | 14 | 51782967 | Intron, downstream, upstream | T/C | 0.08/0.03 | 3.12 (1.81, 5.38) | 1.71E−05 |
SNP, single-nucleotide polymorphism; Chr, chromosome; OR, odds ratio; CI, confidence interval.