Table 3.
Functional characterizations and molecular mechanisms of LINC00511 in the included studies.
| Cancer type | Function | Interacted miRNA | Protein binding | Downstream molecules |
|---|---|---|---|---|
| NSCLC | Cell proliferation, invasion, metastasis and apoptosis | - | EZH2 | p57 |
| BC | Cell proliferation, invasion, maintenance of cancer stem cells characteristic | miR-185-3p | - | E2F1, Nanog |
| PDA | Cell proliferation, invasion and tumor angiogenesis | miR-29b-3p | - | VEGFA |
| CcRCC | Cell proliferation, colony formation and metastasis | miR-625 | - | CCND1 |
| BC | Cell proliferation, apoptosis and radioresistance | miR-185 | - | STXBP4 |
| CC | Cell proliferation, invasion, metastasis and apoptosis | - | - | MRP1, P-GP, Bcl-2, MMP-2 and MMP-9 |
| HC | Cell proliferation, invasion and metastasis | miR-424 | - | - |
| CC | Cell proliferation, invasion and metastasis | - | - | - |
| BC | Cell proliferation and invasion | - | EZH2 | CDKN1B |
BC, breast cancer; CC, cervical cancer; ccRCC, clear cell renal cell carcinoma; HC, hepatocellular carcinoma; NSCLC, non-small cell lung cancer; PDA, pancreatic ductal adenocarcinoma.