Table 3.
Studies using FFPE with methods for biomarker discovery.
| Reference | Year | Author | Country | Biomarker | Material | N | Method | Effect |
|---|---|---|---|---|---|---|---|---|
| 6 | 2010 | Xiao, Z. | China | Cathepsin D Keratin8 SFN Stathmin1 |
FFPE | 40 | 2D liquid chromatography-tandem MS coupled with iTRAQ | Correlation of differential expression with the NPC types |
| 11 | 2016 | Chen, Z. | China | SQSTM1 RAN TRIM29 |
Cell line (FFPE for validation) | 108 | iTRAQ-tagging combined with 2D LC-MS/MS | TRIM29 as a metastasis-promoted protein |
| 19 | 2007 | Chan, C. | China | Annexin II Beta-2-tubulin | Cell-line, FFPE |
40 | 2DGE | Annexin II down-regulation positively associated with node metastasis |
| 20 | 2016 | Yuan, H | China | 14-3-3σ Maspin RKIP GRP78 |
FFPE | 149 | IHC | RKIP for radiosensitive, and GRP78 for radioresistance |