Table 2.

Main medication changes before and after the implementation of the DITSMI model

N = 702 prescriptions, 417 changes	Before	After	p value
First-generation antipsychotic medication	81 (22.1%)	42 (12.9%)	<0.001
Second-generation antipsychotic medication	64 (21.2%)	100 (30.7%)	<0.001
Clozapine	44 (12.0%)	60 (18.2%)	0.021
Olanzapine	14 (3.8%)	36 (11.1%)	0.003
Biperideen	46 (19.9%)	24 (12.9%)	0.026
Benzodiazepines	101 (27.2%)	99 (29.8%)	0.459
Lorazepam	36 (7.1%)	52 (16%)	0.018
Oxazepam	43 (11.7%)	23 (7.1%)	0.033
Anticonvulsants	33 (9.0%)	29 (8.9%)	0.931
Antidepressant medication	34 (9.2%)	24 (7.3%)	0.346
SSRI	24 (6.5%)	19 (5.8%)	0.673
Tri-cyclic antidepressant	10 (2.7%)	5 (1.5%)	0.273
Number of prescriptions (denominator)	370	332

Abbreviations: DITSMI, Diagnose, Indicate, Treat, Severe Mental Illness; SSRI, selective serotonin reuptake inhibitors.