Table 1.
Calcium permeable channels involved in different cancer types.
| Ca2+ permeable channels | Cancer types | Expression profile | Reference | |
|---|---|---|---|---|
| VGCCs | CaV1.2 | Brain, breast, colorectal, pancreas, prostate, uterus, skin and esophageal | Gene upregulation | (Kale et al., 2015; Wang et al., 2015a; Cui et al., 2017; Anderson et al., 2019) |
| CaV1.3 | Breast, prostate, colorectal, bladder, gastric, uterus, lung, brain and esophageal | Gene and protein upregulation and gene downregulation | (Chen et al., 2014; Wang et al., 2015a; Phan et al., 2017; Prevarskaya et al., 2018) | |
| CaV1.4 | Testis | Gene upregulation | (Wang et al., 2015a) | |
| CaV2.1 | Leukemia, sarcoma, ovarian, brain, uterus, lung, cervix, colorectal, esophageal and gastric | Gene upregulation and downregulation | (Hao et al., 2006; Sabates-Bellver et al., 2007; Wang et al., 2015a; Phan et al., 2017) | |
| CaV2.2 | Breast, brain and prostate | Gene up and downregulation | (Sun et al., 2006; Grasso et al., 2012; Wang et al., 2015a; Phan et al., 2017) | |
| CaV3.1 | Breast, glioma, lung, prostate, colorectal, pancreas and gastric | Gene upregulation and downregulation | (Latour et al., 2004; Wang et al., 2015a; Cui et al., 2017; Anderson et al., 2019) | |
| CaV3.2 | Prostate, renal, gastric, ovarian, brain, breast, bladder, lung, colon and skin | Gene and protein up and downregulation | (Gackière et al., 2008; Cui et al., 2017; Phan et al., 2017) | |
| CaV3.3 | Breast, sarcoma, esophagus and gastric | Gene upregulation | (Wang et al., 2015a; Anderson et al., 2019) | |
| TRPs | TRPC1 | Breast, colorectal, esophageal, gastric and liver | Gene and protein upregulation | (Dhennin-Duthille et al., 2011; Villalobos et al., 2016; Cui et al., 2017; Anderson et al., 2019) |
| TRPC3 | Breast and ovarian | Gene and protein upregulation | (Aydar et al., 2009; Yang et al., 2009a; Tao et al., 2013) | |
| TRPC4 | Renal | Gene downregulation | (Veliceasa et al., 2007) | |
| TRPC6 | Breast, liver, stomach, prostate and glia | Gene and protein upregulation | (El Boustany et al., 2008; Guilbert et al., 2008; Aydar et al., 2009; Cai et al., 2009; Ding et al., 2010; Prevarskaya et al., 2018; Anderson et al., 2019) | |
| TRPM6 | Colorectal | Gene downregulation | (Xie et al., 2018; Anderson et al., 2019) | |
| TRPM7 | Breast, pancreas, ovarian, gastric and colorectal | Gene and protein upregulation | (Hoshino et al., 1988; Kim et al., 2008; Middelbeek et al., 2012; Rybarczyk et al., 2012; Wang et al., 2014; Bose et al., 2015; Anderson et al., 2019) | |
| TRPM8 | Pancreas, prostate, bladder, skin, breast, colorectal, and lung | Gene and protein upregulation and gene downregulation | (Schmidt et al., 2006; Prevarskaya et al., 2007; Chodon et al., 2010; Yee et al., 2010; Liu et al., 2014; Cui et al., 2017; Anderson et al., 2019) | |
| TRPV4 | Skin, renal and bladder | Gene and protein downregulation | (Fusi et al., 2014; Mizuno et al., 2014; Cui et al., 2017; Prevarskaya et al., 2018) | |
| TRPV6 | Breast, prostate, thyroid, colon, lung and ovary | Gene and protein upregulation and gene downregulation | (Wissenbach et al., 2001; Zhuang et al., 2002; Bolanz et al., 2008; Dhennin-Duthille et al., 2011; Fan et al., 2014; Cui et al., 2017) | |
| SOCs | ORAI1 | Glia, breast, skin, colorectal, pancreas, esophageal, lung and renal | Gene and protein upregulation | (McAndrew et al., 2011; Motiani et al., 2013a; Kim et al., 2014; Zhu et al., 2014b; Cui et al., 2017; Anderson et al., 2019) |
| ORAI3 | Prostate, breast and lung | Gene and protein upregulation and gene downregulation | (Abeele et al., 2002; Ay et al., 2013; Motiani et al., 2013b; Dubois et al., 2014; Villalobos et al., 2016; Cui et al., 2017) | |
| STIM1 | Glia, cervix, breast, lung, skin, liver, pancreas and colorectal | Gene and protein upregulation | (Scrideli et al., 2008; Chen et al., 2011; McAndrew et al., 2011; Li et al., 2013; Yang et al., 2013; Umemura et al., 2014; Wang et al., 2015b; Wang et al., 2016; Cui et al., 2017; Anderson et al., 2019) | |
| STIM2 | Colorectal, skin, breast and glia | Gene upregulation and protein downregulation | (Ruano et al., 2006; Aytes et al., 2012; Sobradillo et al., 2014; Stanisz et al., 2014; Cui et al., 2017; Anderson et al., 2019) | |