Table 1.
Main Potential Hydroxychloroquine Drug Interactions in Older Adults.
| Drug | ATC | Effects* | Should not Be Coadministered | Potential Interaction: May Require Close Monitoring, Alteration of Drug Dosage or Timing of Administration | Potential Interaction Likely to Be of Weak Intensity. Additional Action/monitoring or Dosage Adjustment Is Unlikely to Be Required | Altered QT/PR | Frequency (%) |
|---|---|---|---|---|---|---|---|
| Amiodarone | C01BD01 | ↑ | X | X | 3.27 | ||
| Rifampicin | J04AB02 | ⇓ | X | 3.4 | |||
| Phenobarbital | N03AA02 | ⇓ | X | 17.4 | |||
| Phenytoin | N03AB02 | ⇓ | X | 1.4 | |||
| Carbamazepine | N03AF01 | ⇓ | X | 1.4 | |||
| Digoxin | C01AA05 | ↑ | X | 1.8 | |||
| Citalopram | N06AB04 | ↔ | X | X | 0.4 | ||
| Dabigatran | B01AE07 | ↑ | X | 5.4 | |||
| Hydroxyzine | N05BB51 | ↔ | X | X | 2.18 | ||
| Nortriptyline | N06AA10 | ↑ | X | X | 0.8 | ||
| Salmeterol | R03AC12 | ↔ | X | X | 0.36 | ||
| Apixaban | B01AF02 | ↑ | X | 2.9 |
Abbreviations: ATC, Anatomical Therapeutic Chemical code.
↑potencial increased exposure of the comedication.
↓potencialdecreased exposure of the comedication.
⇑potencial increased exposure of coronavirus disease 2019 drug.
⇓potencialdecreased exposure of coronavirus disease 2019 drug.
↔ No significant effect.