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. 2020 Apr 24;40(8):2007–2016. doi: 10.1007/s10792-020-01376-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Influence of subretinal fluid on the OCTA flow signal from the choriocapillaris using spectral domain OCTA compared to swept-

source OCTA. Comparison of spectral domain OCTA (SD-OCTA, A–A′″) and swept-source OCTA (SS-OCTA, B–B′″) signals at the level of the choriocapillaris (CC) in patients with acute central serous chorioretinopathy (CSC). Macular edema heatmap (A, B), corresponding OCTA image without (A′, B′) and with pseudocoloration (A″, B″) highlighting increased (red) and decreased OCTA signals (green) and a merged image (A′″, B′″) of a representative patient with acute CSC imaged with SD-OCTA (upper row) and SS-OCTA (bottom row). Asterisks surround the area of increased subretinal fluid (SRF) defined as > 450 µm macular thickness. C–F) Box and whisker plot demonstrating the relative number of increased (red) and decreased OCTA signal (green) in the area with (C, D) and without SRF (E, F) in SD-OCTA and SS-OCTA. Each dot represents one eye. Mann–Whitney U-test, **p < 0.01 ****p < 0.0001. G–J) Density plots of the OCTA choriocapillaris flow signal changes in the presence of SRF using SD-OCTA (yellow) compared to SS-OCTA (blue). G, H) Increased/decreased signal in the area without SRF, I, J) Increased/decreased signal in the area with SRF. The x-axis describes the density of flow signal changes in the respective area, the y-axis the probability of the corresponding percentage. Note that the distributions of SD-OCTA are uniformly broader in comparison with the distribution from SS-OCTA: This hints towards a better signal-to-noise ratio from the latter imaging modality