Table 2.
Summary of the 27 studies included in the quantitative analysis
| Period | Author/Year | Location | Population at risk | Cases of NEC in population at risk | Population at risk | Incidence |
|---|---|---|---|---|---|---|
| 2003–2007 | Stoll et al. 2010 [18] | US | VLBW infants | not reporteda | 9575 | 11.0% |
| 1991–1998 | Llanos et al. 2002 [3] | US | VLBW infants | 47 | 1425 | 3.29% |
| 86/87, 92/93, and 98/99 | Luig et al. 2005 [4] | Australia | Extremely premature | 127 | 1655 | 7.67% |
| 2000 | Holman et al. 2006 [19] | US- 27 states | VLBW infants | 2554 | 58,810 | 4.34% |
| 201–2014 | Youn 2015 [16] | Korea | VLBW infants | 149 | 2326 | 6.41% |
| 2011 | Qian et al. 2017 | China | VLBW infants | 221 | 8727 | 2.53% |
| 1987–2009 | Ahle et al. 2013 [12] | Sweden | VLBW infants | 473 | 17,608 | 2.68% |
| 2009 | Wojkowska-Mach et al. 2014 | Poland | VLBW infants | 79 | 910 | 8.68% |
| 2007 | Boo et al. 2012 [14] | Malaysia | VLBW infants | 222 | 3601 | 6.20% |
| 1998–2004 | Wong et al. 2013 | Australia | VLBW infants | 199 | 2549 | 7.81% |
| 87/88, 93/94,99/2000 | Fanaroff 2003 [20] | US | VLBW infants | 786 | 12,628 | 6.23% |
| 2004–2006 | Chedid et al. 2008 | UAE | VLBW infants | 10 | 173 | 5.78% |
| 2000–20,209 | Agrawel et al. 2015 | Singapore | VLBW infants | 50 | 835 | 6.98% |
| 2008–2010 | Patole et al. 2016 [21] | Australia | Extremely premature | 16 | 250 | 6.40% |
| 2002–2011 | Verstreate et al. 2016 | Belgium | VLBW infants | 158 | 973 | 16.23% |
| 2005–2013 | Harkin et al. 2017 | Finland | Extremely premature | 170 | 1025 | 6.58% |
| 2007–2012 | Andersen et al. 2018 | US-California | Extremely premature | 1360 | 14,941 | 9.10% |
| 2007–2010 | Suciu et al. 2017 [22] | Romania | Extremely premature | 82 | 480 | 17.08% |
| 2010–2014 | Patel et al. 2016 | US-Atlanta | VLBW infants | 44 | 598 | 7.34% |
| 2000–2004 | Bajwa et al. 2011 [23] | Switzerland | Extremely premature | 64 | 1283 | 4.95% |
| 1986–1990 | Narang et al. 1993 [24] | India | VLBW infants | |||
| 2011–2015 | Lodha 2019 [25] | Canada | Extremely premature | 412 | 4680 | 9% |
| 2006–2016 | Boghossian 2018 [26] | United States | VLBW and Extremely premature | 18,129 | 194,736 | 9% |
| 2007–2015 | Persson 2018 [27] | Sweden | Extremely premature | 2077 | 76,360 | 3% |
| 2008–2012 | Suzuki 2018 [28] | Japan | Extremely premature | 296 | 8245 | 4% |
| 2006–2014 | Boghossian 2018 [29] | USA | Extremely premature | 10,376 | 138,869 | 7% |
| 2010–2015 | Beltempo 2018 | Canada | Extremely premature | 778 | 9230 | 8% |
a The number of NEC cases was calculated from the incidence and the baseline population for this study