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. 2020 Jul 13;11:280. doi: 10.1186/s13287-020-01806-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The red fluorescent cells were observed in the rat uterus regions (a–e). The uterus tissue consists of endometrium epithelium, stroma, deep myometrium (DM), superficial myometrium (SM), and serosa, from the inside to the outside (a). CM-Dil-Labeled hUC-MSCs were detected in the serosa and DM (1), in the SM (2), in the stroma (3), but not found in the epithelium of endometrium and gland (4) from the model with hUC group (b). The fluorescent cells were not detected in the same regions of the other groups (c). The number of fluorescent cells in different regions of the uterus in the model with the hUC group was counted. CM-Dil-labeled cells in the stroma region were significantly higher than those in the seroma (*p = 0.000), in the epithelium (*p = 0.000), and in the SM (*p = 0.005). However, there were no differences between the stroma and the DM (^∆p = 0.93), or the DM and the SM (^∆p = 0.33) (d). Detection of the CXCR4 expression around the damaged uterine tissues in terms of protein level. The protein level of CXCR4 in the model with the hUC group was significantly higher than those in the other groups. *p < 0.05 was considered to be a significant difference (e)