Table 3. Pharmacokinetic Parameters for 1 and 2 after Intravenous and Oral Administration.

	1		2		1 as metabolite of 2
parameter	iv	oral	iv	oral	oral
dose (mg/kg)	5	20	5	20	20 of compound 2
Cmax (μM)		5.98		3.54	10.4
Tmax (h)		3		0.5	3
Vd (L/kg)	0.81		11.1
apparent t1/2 (h)	7.3		6.2		10.4
CLtotal (mL·min–1·kg–1)	1.3		21.8
AUC0–∞ (min·μmol·L–1)	8589	7249	523	2152	18430
bioavailability (%)		18.4		93