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. 2020 Jul 13;10:11497. doi: 10.1038/s41598-020-68316-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RCL derived peptide design. (a) Homology model of serpin-3 made by I-TASSER⁴⁶. P1 and P1′ side chains are indicated as stick drawings and P14-P7 residues are in orange. (b) Sequences of RCL derived peptides aligned with P14-P1′ of the serpin-3 RCL. (c) A cartoon sketch of native serpin-3 and the complex with RCL-derived peptide inserted into β-sheet A.